Inhibition of cyclic enzymes by following medications prolongs the metabolism of benzodiazepines. Stimulation of liver enzyme by following medications leads to rapid metabolism of diazepam. Increase rate of metabolism causes decreases drug levels and therapeutic effects.
When administered orally, it is rapidly absorbed by intestinal mucosa and has a relatively fast onset of action. Plasma protein binding rate is very high for benzodiazepine. Peak plasma level determines how soon a medication will cause desired therapeutic effects.
Peak plasma level following administration through different route is as follows. It easily crosses both the blood brain barrier and placenta. brain barrier control the flow of diazepam to brain and spinal cord. Benzodiazepine discontinuation after short-term use does not cause any side effects. But if Benzodiazepine is discontinued after long term use then side effects can be mild to severe in intensity.
The reason for withdrawal symptoms is as "Anal administration xanax." Symptoms of anaphylaxis are as follows. Mild Anal administration xanax symptoms after discontinuation of benzodiazepine is observed in few patients treated for short period.
Severe withdrawal symptoms are observed in patients treated with benzodiazepine for prolonged period, if abruptly discontinued. Withdrawal syndrome may be short or prolonged as described below.
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